The Revenir™ Product Engine
We have created a purpose-built computational drug discovery engine called Revenir™, which captures the biophysical changes caused by mutations in proteins. By examining surface features and numerous biophysical descriptors of both the mutated and wild-type proteins, we build an understanding of that defect and how to correct it in real-time.
We reveal the molecular basis of disease by modeling hidden features of protein dynamics
Dynamic Pocket Hunting
Confidently and reproducibly capture functional allosteric and cryptic pockets with the potential to revert the disease state
Apply real-time ligand-based correction to predict small molecule hits with the power to drive resolution of the disease state
Compound predicted by Revenir™ seamlessly progress from the dry lab to the wet lab for Hit-Lead-Generation
Advantages of Revenir™
The Revenir™ Engine significantly improves on the historical drug discovery process.
Avoids need for high throughput screening
Rapid Identification of Functional Pockets
Robust Identification of Novel Chemical Matter
Unprecedented Hit Rates
Reduction in Time and Cost
Congruence’s pipeline represents both first-in-class and best-in-class potential to address significant
unmet medical needs in a number of high value indications representing multi-billion dollar opportunities.
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