Our Science

Traditional drug development efforts rely on trial and error and artificial, rigid methods that are not capable of capturing and understanding the true essence of proteins.  In reality, proteins are dynamic and interact with the world around them, undergoing conformational transformations as they exert their function.  As universal building blocks of life, they are guided by laws of thermodynamics, physical laws regulating how proteins fold, function and move as they travel through space and time.

The Revenir™ Product Engine

We have created a purpose-built computational drug discovery engine called Revenir™, which captures the biophysical changes caused by mutations in proteins.  By examining surface features and numerous biophysical descriptors of both the mutated and wild-type proteins, we build an understanding of that defect and how to correct it in real-time.

Reveal

We reveal the molecular basis of disease by modeling hidden features of protein dynamics

Dynamic Pocket Hunting

Confidently and reproducibly capture functional allosteric and cryptic pockets with the potential to revert the disease state

Achieve Congruence

Apply real-time ligand-based correction to predict small molecule hits with the power to drive resolution of the disease state

Test

Compound predicted by Revenir™ seamlessly progress from the dry lab to the wet lab for Hit-Lead-Generation

Advantages of Revenir™

The Revenir™ Engine significantly improves on the historical drug discovery process.

Avoids need for high throughput screening

Rapid Identification of Functional Pockets

Robust Identification of Novel Chemical Matter

Unprecedented Hit Rates

Reduction in Time and Cost

Pipeline

Congruence’s pipeline represents both first-in-class and best-in-class potential to address significant
unmet medical needs in a number of high value indications representing multi-billion dollar opportunities.

Publications